Mysimba is a weight loss medicine that is used in obese people in conjunction with diet and exercise to help them lose weight. It is a prescription drug that must be prescribed by a licenced physician.

How does Myssimba work?

Mysimba is a prescription-only weight loss medication that contains two active ingredients: naltrexone and bupropion. Mysimba is available in tablet form, with patients typically taking 1-2 per day, with a maximum of 4 per day. The tablets work by suppressing your appetite, causing you to eat less. The active chemicals are also thought to quell cravings, lessening your urge to eat and making weight reduction more feasible. Mysimba is used to treat those who have a BMI of 30 or more and are overweight.

How effective is Myssimba?

A substantial and rigorous amount of testing must take place before a drug can be licenced for sale. According to data given by the European Medicines Agency, Mysimba was demonstrated to be helpful in lowering body weight in four major studies involving nearly 4500 obese or overweight patients. Patients in the tests were given the medicine or a placebo in conjunction with a weight loss programme that included counselling and food and exercise recommendations.

The European Medicines Agency goes on to explain:

“In three of the studies, the average weight loss in patients treated with Mysimba was around 3.7 to 5.7%, compared with 1.3 to 1.9% with placebo; the proportion of Mysimba-treated patients who achieved 5% weight loss ranged from 28 to 42% compared with 12 to 14% with placebo. About 13 to 22% of those taking Mysimba achieved at least a 10% reduction in weight, while 5 to 6% of placebo-treated patients did so.

In the other study, in which patient counseling was also more intensive, the overall weight loss was greater over the study period: 8.1% with Myssimba and 4.9% with placebo. Some 46% and 30% of patients given Mysimba achieved 5 and 10% weight reductions respectively, compared with 34% and 17% respectively with placebo.

The degree of improvement with Myssimba over placebo was similar using different methods of analysis, although the benefits were smallest with the most conservative methods that assumed patients who did not complete the study would not have seen any improvement. The treatment effect was more marked in patients who completed 56 weeks of treatment, or who had lost at least 5% of their original body weight by 4 months.” A full reference can be found here.

How long does Mysimba last?

When you first start Myssimba, a single pack of 112 tablets lasts 5 weeks.

We recommend that you take your medication as directed. When you use Mysimba, your dose will be gradually increased over a four-week period until you reach the maintenance level. You will continue to take Mysimba at this dosage.


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